UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549


                                  SCHEDULE 13G
                               (Amendment No. 2)*

                    UNDER THE SECURITIES EXCHANGE ACT OF 1934


                        INHALE THERAPEUTIC SYSTEMS, INC.
                        --------------------------------
                                (Name of Issuer)

                                  Common Stock
                        --------------------------------
                         (Title of Class of Securities)

                                   457191-10-4
                        --------------------------------
                                 (CUSIP Number)


*The  remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for any  subsequent  amendment  containing  information  which  would  alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).

                                Page 1 of 9 pages



- ---------------------------                          ---------------------------
CUSIP No. 457191-10-4                   13G               Page 2 of 9 Pages
- ---------------------------                          ---------------------------


- --------- ----------------------------------------------------------------------
   1      NAME OF REPORTING PERSONS
          S.S. OR I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS

          ONSET Enterprise Associates, L.P.
- --------- ----------------------------------------------------------------------
   2      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*            (a)  |_|
                                                                       (b)  |X|
- --------- ----------------------------------------------------------------------
   3      SEC USE ONLY


- --------- ----------------------------------------------------------------------
   4      Citizenship or place of organization

          Delaware
- --------- ----------------------------------------------------------------------
                                 5     SOLE VOTING POWER

         NUMBER OF                     1,473,455
          SHARES              -------- -----------------------------------------
       BENEFICIALLY              6     SHARED VOTING POWER
         OWNED BY
      EACH REPORTING                   - 0 -
       PERSON WITH            -------- -----------------------------------------
                                 7     SOLE DISPOSITIVE POWER

                                       1,473,455
                              -------- -----------------------------------------
                                 8     SHARED DISPOSITIVE POWER

                                       - 0 -
- --------- ----------------------------------------------------------------------
   9      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

          1,473,455
- --------- ----------------------------------------------------------------------
   10     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
                                                                                

- --------- ----------------------------------------------------------------------
   11     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

          12.45%
- --------- ----------------------------------------------------------------------
   12     TYPE OF REPORTING PERSON*

          PN
- --------- ----------------------------------------------------------------------

                      *SEE INSTRUCTION BEFORE FILLING OUT!

                               Page 2 of 9 pages



- ---------------------------                          ---------------------------
CUSIP No. 457191-10-4                   13G               Page 3 of 9 Pages
- ---------------------------                          ---------------------------


- --------- ----------------------------------------------------------------------
   1      NAME OF REPORTING PERSONS
          S.S. OR I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS

          OEA Management, L.P.
- --------- ----------------------------------------------------------------------
   2      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*            (a)  |_|
                                                                       (b)  |X|
- --------- ----------------------------------------------------------------------
   3      SEC USE ONLY


- --------- ----------------------------------------------------------------------
   4      Citizenship or place of organization

          Delaware
- --------- ----------------------------------------------------------------------
                                 5     SOLE VOTING POWER

         NUMBER OF                     1,473,455
          SHARES              -------- -----------------------------------------
       BENEFICIALLY              6     SHARED VOTING POWER
         OWNED BY
      EACH REPORTING                   - 0 -
       PERSON WITH            -------- -----------------------------------------
                                 7     SOLE DISPOSITIVE POWER

                                       1,473,455
                             -------- -----------------------------------------
                                 8     SHARED DISPOSITIVE POWER

                                       - 0 -
- --------- ----------------------------------------------------------------------
   9      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

          1,473,455
- --------- ----------------------------------------------------------------------
   10     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
                                                                            

- --------- ----------------------------------------------------------------------
   11     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

          12.45%
- --------- ----------------------------------------------------------------------
   12     TYPE OF REPORTING PERSON*

          PN
- --------- ----------------------------------------------------------------------

                      *SEE INSTRUCTION BEFORE FILLING OUT!

                               Page 3 of 9 pages



- ---------------------------                          ---------------------------
CUSIP No. 457191-10-4                   13G               Page 4 of 9 Pages
- ---------------------------                          ---------------------------


- --------- ----------------------------------------------------------------------
   1      NAME OF REPORTING PERSONS
          S.S. OR I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS

          Robert F. Kuhling, Jr.
- --------- ----------------------------------------------------------------------
   2      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*            (a)  |_|
                                                                       (b)  |X|

- --------- ----------------------------------------------------------------------
   3      SEC USE ONLY


- --------- ----------------------------------------------------------------------
   4      Citizenship or place of organization

          United States
- --------- ----------------------------------------------------------------------
                                 5     SOLE VOTING POWER

         NUMBER OF                     1,878
          SHARES              -------- -----------------------------------------
       BENEFICIALLY              6     SHARED VOTING POWER
         OWNED BY
      EACH REPORTING                   1,473,455
       PERSON WITH            -------- -----------------------------------------
                                 7     SOLE DISPOSITIVE POWER

                                       1,878
                             -------- -----------------------------------------
                                 8     SHARED DISPOSITIVE POWER

                                       1,473,455
- --------- ----------------------------------------------------------------------
   9      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

          1,475,333
- --------- ----------------------------------------------------------------------
   10     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
                                                                            

- --------- ----------------------------------------------------------------------
   11     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

          12.47%
- --------- ----------------------------------------------------------------------
   12     TYPE OF REPORTING PERSON*

          IN
- --------- ----------------------------------------------------------------------

                      *SEE INSTRUCTION BEFORE FILLING OUT!

                               Page 4 of 9 pages



- ---------------------------                          ---------------------------
CUSIP No. 457191-10-4                   13G               Page 5 of 9 Pages
- ---------------------------                          ---------------------------


- --------- ----------------------------------------------------------------------
   1      NAME OF REPORTING PERSONS
          S.S. OR I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS

          Terry L. Opdendyk
- --------- ----------------------------------------------------------------------
   2      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*            (a)  |_|
                                                                       (b)  |X|

- --------- ----------------------------------------------------------------------
   3      SEC USE ONLY


- --------- ----------------------------------------------------------------------
   4      Citizenship or place of organization

          United States
- --------- ----------------------------------------------------------------------
                                 5     SOLE VOTING POWER

         NUMBER OF                     1,878
          SHARES              -------- -----------------------------------------
       BENEFICIALLY              6     SHARED VOTING POWER
         OWNED BY
      EACH REPORTING                   1,473,455
       PERSON WITH            -------- -----------------------------------------
                                 7     SOLE DISPOSITIVE POWER

                                       1,878
                             -------- -----------------------------------------
                                 8     SHARED DISPOSITIVE POWER

                                       1,473,455
- --------- ----------------------------------------------------------------------
   9      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

          1,475,333
- --------- ----------------------------------------------------------------------
   10     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
                                                                            

- --------- ----------------------------------------------------------------------
   11     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

          12.47%
- --------- ----------------------------------------------------------------------
   12     TYPE OF REPORTING PERSON*

          IN
- --------- ----------------------------------------------------------------------

                      *SEE INSTRUCTION BEFORE FILLING OUT!

                                Page 5 of 9 pages







Item 1.

(a)      Name of Issuer:  Inhale Therapeutic Systems, Inc. ("Issuer")

(b)      Address of Issuer's Principal Executive Offices:

         1001 East Meadow Circle
         Palo Alto, CA  94303

         Item 2.

(a)      Name of Person Filing:

         ONSET Enterprise Associates, L.P. ("OEA")
         OEA Management, L.P. ("OEAM")
         Robert F. Kuhling, Jr. ("Kuhling")
         Terry L. Opdendyk ("Opdendyk")

(b)      Address of Principal Business Office:

         2490 Sand Hill Road
         Menlo Park, CA  94025

(c)      Citizenship/Place of Organization:

         OEA:                       Delaware
         OEAM:                      Delaware
         Kuhling:                   United States
         Opdendyk:                  United States

(d)      Title of Class of Securities:               Common Stock

(e)      CUSIP Number:              457191-10-4

Item 3.        Not applicable.

                                        Page 6 of 9 pages





Item 4         Ownership.


- --------- ------------------------- -------------- ----------------- ---------------- --------------- OEA OEAM Kuhling Opdendyk - --------- ------------------------- -------------- ----------------- ---------------- --------------- (a) Beneficial Ownership 1,473,455 1,473,455 1,475,333 1,475,333 - --------- ------------------------- -------------- ----------------- ---------------- --------------- (b) Percentage of Class 12.45% 12.45% 12.47% 12.47% - --------- ------------------------- -------------- ----------------- ---------------- --------------- (c) Sole Voting Power 1,473,455 1,473,455 1,878 1,878 - --------- ------------------------- -------------- ----------------- ---------------- --------------- Shared Voting Power -0- -0- 1,473,455 1,473,455 - --------- ------------------------- -------------- ----------------- ---------------- --------------- Sole Dispositive Power 1,473,455 1,473,455 -0- -0- - --------- ------------------------- -------------- ----------------- ---------------- --------------- Shared Dispositive Power -0- -0- 1,473,455 1,473,455 - --------- ------------------------- -------------- ----------------- ---------------- ---------------
*In addition to the above, NEA ONSET Partners, Limited Partnership ("NEA ONSET") is a general partner of OEAM and hence, may be deemed to share voting and dispositive power over the 1,473,455 shares beneficially owned by OEAM and OEA. Similarly, each of Cornelius C. Bond, Jr., Frank A. Bonsal, Jr., Nancy L. Dorman, C. Richard Kraunlich, Arthur J. Marks, Thomas C. McConnell, Charles W. Newhall, and C. Woodrow Rea, Jr., the eight general partners of NEA ONSET may be deemed to share any voting and dispositive power deemed to be held by NEA ONSET. Item 5. Ownership of Five Percent or Less of a Class Not applicable. Item 6. Ownership of More than Five Percent on Behalf of Another Person Under certain circumstances set forth in the partnership agreements of each of OEA and OEAM, the general and/or limited partners of each such partnership have the right to receive dividends from, or the proceeds from the sale of, the Common Stock of Issuer beneficially owned by each such partnership. Item 7. Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company. Not applicable. Item 8. Identification and Classification of Members of the Group No reporting person is a member of a group as defined in Section 240.13d-1(b)(1)(ii)(H) of the Act. Item 9. Notice of Dissolution of Group Not applicable. Item 10. Certification Not applicable. EXHIBITS A: Joint Filing Statement Page 7 of 9 pages SIGNATURE After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct. Date: February 13, 1997 ONSET Enterprise Associates, L.P. By: OEA Management, L.P., its general partner By: /s/ Terry L. Opdendyk ----------------------------------- General Partner OEA Management, L.P. By: /s/ Terry L. Opdendyk -------------------------------------------- General Partner /s/ Robert F. Kuhling, Jr. - ----------------------------------------------- Robert F. Kuhling, Jr. /s/ Terry L. Opdendyk - ----------------------------------------------- Terry L. Opdendyk Page 8 of 9 pages EXHIBIT A We, the undersigned, hereby express our agreement that the attached Schedule 13G is filed on behalf of us. Date: February 13, 1997 ONSET Enterprise Associates, L.P. By: OEA Management, L.P., its general partner By: /s/ Terry L. Opdendyk ----------------------------------- General Partner OEA Management, L.P. By: /s/ Terry L. Opdendyk -------------------------------------------- General Partner /s/ Robert F. Kuhling, Jr. - ----------------------------------------------- Robert F. Kuhling, Jr. /s/ Terry L. Opdendyk - ----------------------------------------------- Terry L. Opdendyk Page 9 of 9 pages