UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549


                                  SCHEDULE 13G
                               (Amendment No. 2)*

                    UNDER THE SECURITIES EXCHANGE ACT OF 1934


                        INHALE THERAPEUTIC SYSTEMS, INC.
                        --------------------------------
                                (Name of Issuer)

                                  Common Stock
                        --------------------------------
                         (Title of Class of Securities)

                                   457191-10-4
                        --------------------------------
                                 (CUSIP Number)


*The  remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for any  subsequent  amendment  containing  information  which  would  alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).

                                Page 1 of 9 pages


<PAGE>

- ---------------------------                          ---------------------------
CUSIP No. 457191-10-4                   13G               Page 2 of 9 Pages
- ---------------------------                          ---------------------------


- --------- ----------------------------------------------------------------------
   1      NAME OF REPORTING PERSONS
          S.S. OR I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS

          ONSET Enterprise Associates, L.P.
- --------- ----------------------------------------------------------------------
   2      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*            (a)  |_|
                                                                       (b)  |X|
- --------- ----------------------------------------------------------------------
   3      SEC USE ONLY


- --------- ----------------------------------------------------------------------
   4      Citizenship or place of organization

          Delaware
- --------- ----------------------------------------------------------------------
                                 5     SOLE VOTING POWER

         NUMBER OF                     1,473,455
          SHARES              -------- -----------------------------------------
       BENEFICIALLY              6     SHARED VOTING POWER
         OWNED BY
      EACH REPORTING                   - 0 -
       PERSON WITH            -------- -----------------------------------------
                                 7     SOLE DISPOSITIVE POWER

                                       1,473,455
                              -------- -----------------------------------------
                                 8     SHARED DISPOSITIVE POWER

                                       - 0 -
- --------- ----------------------------------------------------------------------
   9      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

          1,473,455
- --------- ----------------------------------------------------------------------
   10     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
                                                                                

- --------- ----------------------------------------------------------------------
   11     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

          12.45%
- --------- ----------------------------------------------------------------------
   12     TYPE OF REPORTING PERSON*

          PN
- --------- ----------------------------------------------------------------------

                      *SEE INSTRUCTION BEFORE FILLING OUT!

                               Page 2 of 9 pages


<PAGE>

- ---------------------------                          ---------------------------
CUSIP No. 457191-10-4                   13G               Page 3 of 9 Pages
- ---------------------------                          ---------------------------


- --------- ----------------------------------------------------------------------
   1      NAME OF REPORTING PERSONS
          S.S. OR I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS

          OEA Management, L.P.
- --------- ----------------------------------------------------------------------
   2      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*            (a)  |_|
                                                                       (b)  |X|
- --------- ----------------------------------------------------------------------
   3      SEC USE ONLY


- --------- ----------------------------------------------------------------------
   4      Citizenship or place of organization

          Delaware
- --------- ----------------------------------------------------------------------
                                 5     SOLE VOTING POWER

         NUMBER OF                     1,473,455
          SHARES              -------- -----------------------------------------
       BENEFICIALLY              6     SHARED VOTING POWER
         OWNED BY
      EACH REPORTING                   - 0 -
       PERSON WITH            -------- -----------------------------------------
                                 7     SOLE DISPOSITIVE POWER

                                       1,473,455
                             -------- -----------------------------------------
                                 8     SHARED DISPOSITIVE POWER

                                       - 0 -
- --------- ----------------------------------------------------------------------
   9      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

          1,473,455
- --------- ----------------------------------------------------------------------
   10     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
                                                                            

- --------- ----------------------------------------------------------------------
   11     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

          12.45%
- --------- ----------------------------------------------------------------------
   12     TYPE OF REPORTING PERSON*

          PN
- --------- ----------------------------------------------------------------------

                      *SEE INSTRUCTION BEFORE FILLING OUT!

                               Page 3 of 9 pages


<PAGE>

- ---------------------------                          ---------------------------
CUSIP No. 457191-10-4                   13G               Page 4 of 9 Pages
- ---------------------------                          ---------------------------


- --------- ----------------------------------------------------------------------
   1      NAME OF REPORTING PERSONS
          S.S. OR I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS

          Robert F. Kuhling, Jr.
- --------- ----------------------------------------------------------------------
   2      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*            (a)  |_|
                                                                       (b)  |X|

- --------- ----------------------------------------------------------------------
   3      SEC USE ONLY


- --------- ----------------------------------------------------------------------
   4      Citizenship or place of organization

          United States
- --------- ----------------------------------------------------------------------
                                 5     SOLE VOTING POWER

         NUMBER OF                     1,878
          SHARES              -------- -----------------------------------------
       BENEFICIALLY              6     SHARED VOTING POWER
         OWNED BY
      EACH REPORTING                   1,473,455
       PERSON WITH            -------- -----------------------------------------
                                 7     SOLE DISPOSITIVE POWER

                                       1,878
                             -------- -----------------------------------------
                                 8     SHARED DISPOSITIVE POWER

                                       1,473,455
- --------- ----------------------------------------------------------------------
   9      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

          1,475,333
- --------- ----------------------------------------------------------------------
   10     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
                                                                            

- --------- ----------------------------------------------------------------------
   11     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

          12.47%
- --------- ----------------------------------------------------------------------
   12     TYPE OF REPORTING PERSON*

          IN
- --------- ----------------------------------------------------------------------

                      *SEE INSTRUCTION BEFORE FILLING OUT!

                               Page 4 of 9 pages


<PAGE>

- ---------------------------                          ---------------------------
CUSIP No. 457191-10-4                   13G               Page 5 of 9 Pages
- ---------------------------                          ---------------------------


- --------- ----------------------------------------------------------------------
   1      NAME OF REPORTING PERSONS
          S.S. OR I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS

          Terry L. Opdendyk
- --------- ----------------------------------------------------------------------
   2      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*            (a)  |_|
                                                                       (b)  |X|

- --------- ----------------------------------------------------------------------
   3      SEC USE ONLY


- --------- ----------------------------------------------------------------------
   4      Citizenship or place of organization

          United States
- --------- ----------------------------------------------------------------------
                                 5     SOLE VOTING POWER

         NUMBER OF                     1,878
          SHARES              -------- -----------------------------------------
       BENEFICIALLY              6     SHARED VOTING POWER
         OWNED BY
      EACH REPORTING                   1,473,455
       PERSON WITH            -------- -----------------------------------------
                                 7     SOLE DISPOSITIVE POWER

                                       1,878
                             -------- -----------------------------------------
                                 8     SHARED DISPOSITIVE POWER

                                       1,473,455
- --------- ----------------------------------------------------------------------
   9      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

          1,475,333
- --------- ----------------------------------------------------------------------
   10     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
                                                                            

- --------- ----------------------------------------------------------------------
   11     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

          12.47%
- --------- ----------------------------------------------------------------------
   12     TYPE OF REPORTING PERSON*

          IN
- --------- ----------------------------------------------------------------------

                      *SEE INSTRUCTION BEFORE FILLING OUT!

                                Page 5 of 9 pages




<PAGE>



Item 1.

(a)      Name of Issuer:  Inhale Therapeutic Systems, Inc. ("Issuer")

(b)      Address of Issuer's Principal Executive Offices:

         1001 East Meadow Circle
         Palo Alto, CA  94303

         Item 2.

(a)      Name of Person Filing:

         ONSET Enterprise Associates, L.P. ("OEA")
         OEA Management, L.P. ("OEAM")
         Robert F. Kuhling, Jr. ("Kuhling")
         Terry L. Opdendyk ("Opdendyk")

(b)      Address of Principal Business Office:

         2490 Sand Hill Road
         Menlo Park, CA  94025

(c)      Citizenship/Place of Organization:

         OEA:                       Delaware
         OEAM:                      Delaware
         Kuhling:                   United States
         Opdendyk:                  United States

(d)      Title of Class of Securities:               Common Stock

(e)      CUSIP Number:              457191-10-4

Item 3.        Not applicable.

                                        Page 6 of 9 pages



<PAGE>


<TABLE>
Item 4         Ownership.


<CAPTION>
- --------- ------------------------- -------------- ----------------- ---------------- ---------------
                                          OEA             OEAM           Kuhling          Opdendyk
- --------- ------------------------- -------------- ----------------- ---------------- ---------------

<S>                                    <C>             <C>              <C>              <C>      
(a)       Beneficial Ownership         1,473,455       1,473,455        1,475,333        1,475,333
- --------- ------------------------- -------------- ----------------- ---------------- ---------------

(b)       Percentage of Class           12.45%           12.45%           12.47%           12.47%
- --------- ------------------------- -------------- ----------------- ---------------- ---------------

(c)       Sole Voting Power            1,473,455       1,473,455          1,878            1,878
- --------- ------------------------- -------------- ----------------- ---------------- ---------------

          Shared Voting Power             -0-             -0-           1,473,455        1,473,455
- --------- ------------------------- -------------- ----------------- ---------------- ---------------

          Sole Dispositive Power       1,473,455       1,473,455           -0-              -0-
- --------- ------------------------- -------------- ----------------- ---------------- ---------------

          Shared Dispositive Power        -0-             -0-           1,473,455        1,473,455
- --------- ------------------------- -------------- ----------------- ---------------- ---------------
</TABLE>


*In addition to the above, NEA ONSET Partners, Limited Partnership ("NEA ONSET")
is a general  partner  of OEAM and  hence,  may be deemed  to share  voting  and
dispositive power over the 1,473,455 shares  beneficially owned by OEAM and OEA.
Similarly,  each of  Cornelius C. Bond,  Jr.,  Frank A.  Bonsal,  Jr.,  Nancy L.
Dorman, C. Richard Kraunlich,  Arthur J. Marks, Thomas C. McConnell,  Charles W.
Newhall, and C. Woodrow Rea, Jr., the eight general partners of NEA ONSET may be
deemed to share any voting and dispositive power deemed to be held by NEA ONSET.

Item 5.        Ownership of Five Percent or Less of a Class

Not applicable.

Item 6.        Ownership of More than Five Percent on Behalf of Another Person

Under certain  circumstances set forth in the partnership  agreements of each of
OEA and OEAM, the general and/or limited  partners of each such partnership have
the right to  receive  dividends  from,  or the  proceeds  from the sale of, the
Common Stock of Issuer beneficially owned by each such partnership.

Item 7.        Identification   and   Classification  of  the  Subsidiary  Which
               Acquired the  Security  Being  Reported on By the Parent  Holding
               Company.

Not applicable.

Item 8.        Identification and Classification of Members of the Group

No   reporting   person  is  a  member  of  a  group  as   defined   in  Section
240.13d-1(b)(1)(ii)(H) of the Act.

Item 9.        Notice of Dissolution of Group

Not applicable.

Item 10.       Certification

Not applicable.

EXHIBITS

A:       Joint Filing Statement

                                Page 7 of 9 pages



<PAGE>



                                    SIGNATURE

         After reasonable  inquiry and to the best of my knowledge and belief, I
certify that the information  set forth in this statement is true,  complete and
correct.


Date:    February 13, 1997



ONSET Enterprise Associates, L.P.

By:      OEA Management, L.P., its general partner



         By:      /s/ Terry L. Opdendyk
            -----------------------------------
                  General Partner


OEA Management, L.P.



By:      /s/ Terry L. Opdendyk
   --------------------------------------------
         General Partner



         /s/ Robert F. Kuhling, Jr.
- -----------------------------------------------
Robert F. Kuhling, Jr.



         /s/ Terry L. Opdendyk
- -----------------------------------------------
Terry L. Opdendyk


                                Page 8 of 9 pages



<PAGE>


                                    EXHIBIT A

         We, the  undersigned,  hereby  express our agreement  that the attached
Schedule 13G is filed on behalf of us.



Date:    February 13, 1997



ONSET Enterprise Associates, L.P.

By:      OEA Management, L.P., its general partner



         By:      /s/ Terry L. Opdendyk
            -----------------------------------
                 General Partner


OEA Management, L.P.



By:      /s/ Terry L. Opdendyk
   --------------------------------------------
         General Partner



         /s/ Robert F. Kuhling, Jr.
- -----------------------------------------------
Robert F. Kuhling, Jr.



         /s/ Terry L. Opdendyk
- -----------------------------------------------
Terry L. Opdendyk



                                        Page 9 of 9 pages