UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549


                                  SCHEDULE 13G
                               (Amendment No. 3)*

                    UNDER THE SECURITIES EXCHANGE ACT OF 1934


                        INHALE THERAPEUTIC SYSTEMS, INC.
                        --------------------------------
                                (Name of Issuer)

                                  Common Stock
                        --------------------------------
                         (Title of Class of Securities)

                                   457191-10-4
                        --------------------------------
                                 (CUSIP Number)


*The  remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for any  subsequent  amendment  containing  information  which  would  alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).

                                Page 1 of 9 pages



- ---------------------------                          ---------------------------
CUSIP No. 457191-10-4                   13G               Page 2 of 9 Pages
- ---------------------------                          ---------------------------


- --------- ----------------------------------------------------------------------
   1      NAME OF REPORTING PERSONS
          S.S. OR I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS

          ONSET Enterprise Associates, L.P.
- --------- ----------------------------------------------------------------------
   2      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*            (a)  |_|
                                                                       (b)  |X|
- --------- ----------------------------------------------------------------------
   3      SEC USE ONLY


- --------- ----------------------------------------------------------------------
   4      Citizenship or place of organization

          Delaware
- --------- ----------------------------------------------------------------------
                                 5     SOLE VOTING POWER

         NUMBER OF                     - 0 -
          SHARES              -------- -----------------------------------------
       BENEFICIALLY              6     SHARED VOTING POWER
         OWNED BY
      EACH REPORTING                   - 0 -
       PERSON WITH            -------- -----------------------------------------
                                 7     SOLE DISPOSITIVE POWER

                                       - 0 -
                              -------- -----------------------------------------
                                 8     SHARED DISPOSITIVE POWER

                                       - 0 -
- --------- ----------------------------------------------------------------------
   9      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

          - 0 - 
- --------- ----------------------------------------------------------------------
   10     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
                                                                                

- --------- ----------------------------------------------------------------------
   11     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

          0.00%
- --------- ----------------------------------------------------------------------
   12     TYPE OF REPORTING PERSON*

          PN
- --------- ----------------------------------------------------------------------

                      *SEE INSTRUCTION BEFORE FILLING OUT!

                               Page 2 of 9 pages



- ---------------------------                          ---------------------------
CUSIP No. 457191-10-4                   13G               Page 3 of 9 Pages
- ---------------------------                          ---------------------------


- --------- ----------------------------------------------------------------------
   1      NAME OF REPORTING PERSONS
          S.S. OR I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS

          OEA Management, L.P.
- --------- ----------------------------------------------------------------------
   2      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*            (a)  |_|
                                                                       (b)  |X|
- --------- ----------------------------------------------------------------------
   3      SEC USE ONLY


- --------- ----------------------------------------------------------------------
   4      Citizenship or place of organization

          Delaware
- --------- ----------------------------------------------------------------------
                                 5     SOLE VOTING POWER

         NUMBER OF                     - 0 -
          SHARES              -------- -----------------------------------------
       BENEFICIALLY              6     SHARED VOTING POWER
         OWNED BY
      EACH REPORTING                   - 0 -
       PERSON WITH            -------- -----------------------------------------
                                 7     SOLE DISPOSITIVE POWER

                                       - 0 -
                             -------- -----------------------------------------
                                 8     SHARED DISPOSITIVE POWER

                                       - 0 -
- --------- ----------------------------------------------------------------------
   9      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

          - 0 -
- --------- ----------------------------------------------------------------------
   10     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
                                                                            

- --------- ----------------------------------------------------------------------
   11     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

          0.00%
- --------- ----------------------------------------------------------------------
   12     TYPE OF REPORTING PERSON*

          PN
- --------- ----------------------------------------------------------------------

                      *SEE INSTRUCTION BEFORE FILLING OUT!

                               Page 3 of 9 pages



- ---------------------------                          ---------------------------
CUSIP No. 457191-10-4                   13G               Page 4 of 9 Pages
- ---------------------------                          ---------------------------


- --------- ----------------------------------------------------------------------
   1      NAME OF REPORTING PERSONS
          S.S. OR I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS

          Robert F. Kuhling, Jr.
- --------- ----------------------------------------------------------------------
   2      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*            (a)  |_|
                                                                       (b)  |X|

- --------- ----------------------------------------------------------------------
   3      SEC USE ONLY


- --------- ----------------------------------------------------------------------
   4      Citizenship or place of organization

          United States
- --------- ----------------------------------------------------------------------
                                 5     SOLE VOTING POWER

         NUMBER OF                     108,992
          SHARES              -------- -----------------------------------------
       BENEFICIALLY              6     SHARED VOTING POWER
         OWNED BY
      EACH REPORTING                   - 0 -
       PERSON WITH            -------- -----------------------------------------
                                 7     SOLE DISPOSITIVE POWER

                                       108,992
                             -------- -----------------------------------------
                                 8     SHARED DISPOSITIVE POWER

                                       - 0 -
- --------- ----------------------------------------------------------------------
   9      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

          108,992
- --------- ----------------------------------------------------------------------
   10     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
                                                                            

- --------- ----------------------------------------------------------------------
   11     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

          0.79%
- --------- ----------------------------------------------------------------------
   12     TYPE OF REPORTING PERSON*

          IN
- --------- ----------------------------------------------------------------------

                      *SEE INSTRUCTION BEFORE FILLING OUT!

                               Page 4 of 9 pages



- ---------------------------                          ---------------------------
CUSIP No. 457191-10-4                   13G               Page 5 of 9 Pages
- ---------------------------                          ---------------------------


- --------- ----------------------------------------------------------------------
   1      NAME OF REPORTING PERSONS
          S.S. OR I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS

          Terry L. Opdendyk
- --------- ----------------------------------------------------------------------
   2      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*            (a)  |_|
                                                                       (b)  |X|

- --------- ----------------------------------------------------------------------
   3      SEC USE ONLY


- --------- ----------------------------------------------------------------------
   4      Citizenship or place of organization

          United States
- --------- ----------------------------------------------------------------------
                                 5     SOLE VOTING POWER

         NUMBER OF                     108,992
          SHARES              -------- -----------------------------------------
       BENEFICIALLY              6     SHARED VOTING POWER
         OWNED BY
      EACH REPORTING                   - 0 -
       PERSON WITH            -------- -----------------------------------------
                                 7     SOLE DISPOSITIVE POWER

                                       108,992
                             -------- -----------------------------------------
                                 8     SHARED DISPOSITIVE POWER

                                       - 0 -
- --------- ----------------------------------------------------------------------
   9      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

          108,992
- --------- ----------------------------------------------------------------------
   10     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*
                                                                            

- --------- ----------------------------------------------------------------------
   11     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

          0.79%
- --------- ----------------------------------------------------------------------
   12     TYPE OF REPORTING PERSON*

          IN
- --------- ----------------------------------------------------------------------

                      *SEE INSTRUCTION BEFORE FILLING OUT!

                                Page 5 of 9 pages







Item 1.

(a)      Name of Issuer:  Inhale Therapeutic Systems, Inc. ("Issuer")

(b)      Address of Issuer's Principal Executive Offices:

         1525 Industrial Way
         Belmont, CA 94002

         Item 2.

(a)      Name of Person Filing:

         ONSET Enterprise Associates, L.P. ("OEA")
         OEA Management, L.P. ("OEAM")
         Robert F. Kuhling, Jr. ("Kuhling")
         Terry L. Opdendyk ("Opdendyk")

(b)      Address of Principal Business Office:

         2490 Sand Hill Road
         Menlo Park, CA  94025

(c)      Citizenship/Place of Organization:

         OEA:                       Delaware
         OEAM:                      Delaware
         Kuhling:                   United States
         Opdendyk:                  United States

(d)      Title of Class of Securities:               Common Stock

(e)      CUSIP Number:              457191-10-4

Item 3.        Not applicable.

                                        Page 6 of 9 pages





Item 4.        Ownership.


- --------- ------------------------- -------------- ----------------- ---------------- --------------- OEA OEAM Kuhling Opdendyk - --------- ------------------------- -------------- ----------------- ---------------- --------------- (a) Beneficial Ownership -0- -0- 108,992 108,992 - --------- ------------------------- -------------- ----------------- ---------------- --------------- (b) Percentage of Class 0.00% 0.00% 0.79% 0.79% - --------- ------------------------- -------------- ----------------- ---------------- --------------- (c) Sole Voting Power -0- -0- 108,992 108,992 - --------- ------------------------- -------------- ----------------- ---------------- --------------- Shared Voting Power -0- -0- -0- -0- - --------- ------------------------- -------------- ----------------- ---------------- --------------- Sole Dispositive Power -0- -0- 108,992 108,992 - --------- ------------------------- -------------- ----------------- ---------------- --------------- Shared Dispositive Power -0- -0- -0- -0- - --------- ------------------------- -------------- ----------------- ---------------- ---------------
Item 5. Ownership of Five Percent or Less of a Class If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than five percent of the class of securities, check the following: [X] Item 6. Ownership of More than Five Percent on Behalf of Another Person Not applicable. Item 7. Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company. Not applicable. Item 8. Identification and Classification of Members of the Group No reporting person is a member of a group as defined in Section 240.13d-1(b)(1)(ii)(H) of the Act. Item 9. Notice of Dissolution of Group Not applicable. Item 10. Certification Not applicable. EXHIBITS A: Joint Filing Statement Page 7 of 9 pages SIGNATURE After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct. Date: February 12, 1998 ONSET Enterprise Associates, L.P. By: OEA Management, L.P., its general partner By: /s/ Terry L. Opdendyk ----------------------------------- General Partner OEA Management, L.P. By: /s/ Terry L. Opdendyk -------------------------------------------- General Partner /s/ Robert F. Kuhling, Jr. - ----------------------------------------------- Robert F. Kuhling, Jr. /s/ Terry L. Opdendyk - ----------------------------------------------- Terry L. Opdendyk Page 8 of 9 pages EXHIBIT A We, the undersigned, hereby express our agreement that the attached Schedule 13G is filed on behalf of us. Date: February 12, 1998 ONSET Enterprise Associates, L.P. By: OEA Management, L.P., its general partner By: /s/ Terry L. Opdendyk ----------------------------------- General Partner OEA Management, L.P. By: /s/ Terry L. Opdendyk -------------------------------------------- General Partner /s/ Robert F. Kuhling, Jr. - ----------------------------------------------- Robert F. Kuhling, Jr. /s/ Terry L. Opdendyk - ----------------------------------------------- Terry L. Opdendyk Page 9 of 9 pages