SECURITIES AND EXCHANGE COMMISSION

                             WASHINGTON, D.C. 20549

                                    FORM 8-K

                                 CURRENT REPORT

                       Pursuant to Section 13 or 15(d) of
                       The Securities Exchange Act of 1934

                                OCTOBER 27, 2000
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                Date of Report (Date of earliest event reported)

                        INHALE THERAPEUTIC SYSTEMS, INC.
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             (Exact name of registrant as specified in its charter)

          Delaware                   023556                94-3134940
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     (State or other               (Commission         (I.R.S. Employer
jurisdiction of incorporation)     File Number)        Identification No.)


                               150 Industrial Road
                              San Carlos, CA 94070
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                    (Address of principal executive offices)

                                 (650) 631-3100
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              (Registrant's telephone number, including area code)


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                   (Former name, if changed since last report)






ITEM 5.  OTHER EVENTS

            On October 27, 2000, Inhale Therapeutic Systems, Inc. announced that
the initial purchasers have exercised their $30 million over-allotment option
granted pursuant to a purchase agreement dated October 11, 2000 with respect to
the Company's 3.5% convertible subordinated notes due 2007. The closing of the
over-allotment increases the aggregate principal amount of convertible
subordinated notes to $230 million. A press release relating to the issuance is
attached hereto as Exhibit 99.1.

ITEM 7.  FINANCIAL STATEMENTS, PRO FORMA FINANCIAL INFORMATION AND EXHIBITS

         (c)      Exhibits

                  99.1     Press Release dated October 27, 2000




                                       2.




                                   SIGNATURES

         Pursuant to the requirements of the Securities Exchange Act of 1934,
the registrant has duly caused this report to be signed on its behalf by the
undersigned hereunto duly authorized.

                                       INHALE THERAPEUTIC SYSTEMS, INC.

Dated:    October 30, 2000             By:/s/ Brigid A. Makes
                                          -------------------------------
                                          Brigid A. Makes,
                                          Chief Financial Officer and
                                          Vice President,
                                          Finance and Administration


                                       3.


                                  EXHIBIT 99.1

CONTACT:  JOYCE STRAND (650) 631-3138

          INHALE ANNOUNCES EXERCISE OF $30 MILLION OVER-ALLOTMENT OF
                                CONVERTIBLE NOTES

SAN CARLOS, CALIF., OCTOBER 27, 2000 - Inhale Therapeutic Systems, Inc.
(Nasdaq:INHL) today announced that the initial purchasers have exercised their
$30 million over-allotment option granted pursuant to a purchase agreement dated
October 11, 2000 with respect to Inhale's 3.5% convertible subordinated notes
due in 2007. The closing of the over-allotment increases the aggregate principal
amount of convertible subordinated notes to $230 million. The offering of the
notes was made to qualified institutional buyers under Rule 144A of the
Securities Act of 1933, as amended.

Interest on the notes accrues at a rate of 3.5% per year, subject to adjustment
in certain circumstances. The notes mature in 2007 and are convertible into
shares of Inhale's common stock at a conversion price of $50.46 per share,
subject to adjustment in certain circumstances.

Inhale intends to use the proceeds from the offering to invest in various
product development programs relating to the company's business strategy, to
accelerate development of its next-generation technologies, and to provide
resources for potential acquisition and development of complementary
technologies, as well as for working capital and other general corporate
purposes. A portion of the proceeds will also be used to make cash payments to
certain holders of the 5% convertible subordinated notes due 2007 issued in
February 2000 in exchange for their agreement to convert into common stock. The
Company has negotiated to have approximately $105 million of these notes
exchanged into 2.7 million shares of common stock for an estimated $16 million.
The offering is subject to market conditions and other factors.

The notes offered will not be registered under the Securities Act or applicable
state securities laws, and may not be offered or sold in the United States
absent registration under the Securities Act and applicable state securities
laws or available exemptions from the registration requirements.

This release contains forward-looking statements that reflect management's
current views as to Inhale's business strategy, product and technology
development plans and funding, collaborative arrangements, clinical trials, and
other future events and operations. These forward-looking statements involve
uncertainties and other risks that are detailed in Inhale's reports and other
filings with the SEC, including its Form 10-Q for the fiscal quarter ended June
30, 2000. Actual results could differ materially from these forward-looking
statements.

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                                       4.