UNITED STATES 

SECURITIES AND EXCHANGE COMMISSION 

Washington, D.C. 20549

 

FORM 8-K

 

CURRENT REPORT

 

Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

 

Date of report (Date of earliest event reported): February 28, 2019

 

NEKTAR THERAPEUTICS 

(Exact Name of Registrant as Specified in Charter)

 

Delaware 0-24006 94-3134940

(State or Other Jurisdiction

of Incorporation)

(Commission 

File Number) 

(IRS Employer 

Identification No.) 

 

455 Mission Bay Boulevard South 

San Francisco, California 94158 

(Address of Principal Executive Offices and Zip Code)

 

Registrant’s telephone number, including area code: (415) 482-5300

 

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

  

Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

 

Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

 

Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

 

Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

 

Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§240.12b-2 of this chapter).

  

Emerging growth company ☐

 

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐

  

 

 

 

Item 2.02 Results of Operations and Financial Condition.

 

On February 28, 2019, Nektar Therapeutics, a Delaware corporation (“Nektar”), issued a press release (the “Press Release”) announcing its financial results for the quarter and year ended December 31, 2018. A copy of the Press Release is furnished herewith as Exhibit 99.1.

 

On February 21, 2019, Nektar announced that it would hold a Webcast conference call on February 28, 2019 to review its financial results for the quarter and year ended December 31, 2018. This conference call is accessible through a link that is posted on the home page and Investors section of the Nektar website: http://www.nektar.com.

 

The information in this report, including the exhibit hereto, is being furnished and shall not be deemed “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended, or otherwise subject to the liabilities of that Section or Sections 11 and 12(a)(2) of the Securities Act of 1933, as amended. The information contained herein and in the accompanying exhibit shall not be incorporated by reference into any filing with the Securities and Exchange Commission made by Nektar Therapeutics, whether made before or after the date hereof, regardless of any general incorporation language in such filing.

 

Item 9.01 Financial Statements and Exhibits.

 

Exhibit
No.
  Description
   
99.1   Press release titled “Nektar Therapeutics Reports Fourth Quarter and Year-End 2018 Financial Results” issued by Nektar Therapeutics on February 28, 2019.

 

 

 

  

SIGNATURES

 

Pursuant to the requirement of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized.

 

  By: /s/ Mark A. Wilson
     Mark A. Wilson
    General Counsel and Secretary
     
  Date:       February 28, 2019

 

 

 

Exhibit 99.1

 

(LOGO)    

 

Nektar Therapeutics Reports Fourth Quarter and Year-End 2018 Financial Results

SAN FRANCISCO, Feb. 28, 2019 /PRNewswire/ -- Nektar Therapeutics (Nasdaq: NKTR) today reported financial results for the fourth quarter and full year ended December 31, 2018.

Cash and investments in marketable securities at December 31, 2018 were $1.9 billion as compared to $353.2 million at December 31, 2017.

"2018 was a remarkable year for Nektar accentuated by new collaborations with leading pharmaceutical companies that validate the depth and innovation of our pipeline," said Howard W. Robin, President and Chief Executive Officer of Nektar. "We entered 2019 in an exceptionally strong financial position. We are working closely with the FDA during the ongoing review of our NDA for NKTR-181 while simultaneously preparing for a potential commercial launch later this year. We continue to design and execute on our broad registrational program for NKTR-214 (bempegaldesleukin1) with our partner Bristol-Myers Squibb. NKTR-358 is advancing in the ongoing clinical study in lupus patients and two new studies in additional auto-immune conditions are planned to start in 2019.NKTR-262, our TLR agonist is being evaluated in a Phase 1/2 study and finally, NKTR-255, our next I-O candidate is slated to move into the clinic first in patients with multiple myeloma and then in combination with CAR-T therapy."

 

Summary of Financial Results

 

Revenue for the fourth quarter of 2018 was $39.8 million as compared to $95.5 million in the fourth quarter of 2017. Revenue in the fourth quarter of 2017 included a total of $60.0 million of non-recurring revenue related to a new sublicense agreement, a contract settlement agreement and the recognition of deferred revenue from several collaboration agreements. Revenue for the year ended December 31, 2018 was $1.2 billion as compared to $307.7 million in 2017 and included the recognition of $1.06 billion of license revenue from the Bristol-Myers Squibb collaboration agreement.

Total operating costs and expenses in the fourth quarter of 2018 were $140.1 million as compared to $119.5 million in the fourth quarter of 2017. Total operating costs and expenses for 2018 were $505.4 million as compared to $367.4 million in 2017. Total operating costs and expenses increased primarily as a result of increased research and development (R&D) expense.

R&D expense in the fourth quarter of 2018 was $108.9 million as compared to $81.4 million for the fourth quarter of 2017. R&D expense for the year ended December 31, 2018 was $399.5 million as compared to $268.5 million in 2017. R&D expense was higher in the fourth quarter and full year 2018 as compared to the same periods in 2017 primarily because of expenses for our pipeline programs, including the continued development of bempegaldesleukin in Phase 2 and registrational studies and related manufacturing costs, costs related to the NKTR-181 New Drug Application and NKTR-181 pre-commercial manufacturing, Phase 1 clinical studies of NKTR-358, the Phase 1 study of NKTR-262 in combination with bempegaldesleukin and IND-enabling activities for NKTR-255.

General and administrative (G&A) expense was $23.8 million in the fourth quarter of 2018 as compared to $12.3 million in the fourth quarter of 2017. G&A expense for 2018 was $81.4 million as compared to $52.4 million in 2017. G&A expense was higher in the fourth quarter and full year 2018 as compared to the same periods in 2017 primarily due to an increase in non-cash stock-based compensation expense.

Net loss for the fourth quarter of 2018 was $98.2 million or $0.57 basic and diluted loss per share as compared to a net loss of $33.8 million or $0.21 basic and diluted loss per share in the fourth quarter of 2017. Net income for the year ended December 31, 2018 was $681.3 million or $3.78 diluted earnings per share as compared to a net loss of $96.7 million or $0.62 basic and diluted loss per share in 2017.

 

 

2018 and Year-to-Date Business Highlights

In February 2019, Nektar presented clinical data from first-line Stage IV urothelial carcinoma patients enrolled in the PIVOT-02 study of bempegaldesleukin with nivolumab at the 2019 ASCO Genitourinary Cancers Symposium.
In December 2018, Nektar and Gilead entered into a research collaboration to explore the potential of NKTR-255, an IL-15 agonist, in virology. The collaboration will evaluate NKTR-255 in combination with antiretroviral therapies in Gilead's portfolio.
In December 2018, Nektar and Bristol-Myers Squibb initiated PIVOT-10, a potential registrational study evaluating bempegaldesleukin with nivolumab in cisplatin-ineligible urothelial carcinoma patients whose tumors express PD-L1 (Combined Positive Score < 10).
In December 2018, Nektar and Bristol-Myers Squibb initiated PIVOT-09, a Phase 3 study of bempegaldesleukin with nivolumab versus tyrosine kinase inhibitor (TKI) monotherapy in patients with advanced metastatic renal cell carcinoma.
In November 2018, Nektar presented data for first-line Stage IV melanoma patients from the ongoing PIVOT-02 study at the 2018 Society for Immunotherapy of Cancer Annual Meeting.
In November 2018, Nektar entered into a new clinical collaboration with Pfizer Inc. to evaluate several combination regimens in multiple cancer settings including metastatic castration-resistant prostate cancer (mCRPC) and squamous cell carcinoma of the head and neck (SCCHN). Under the collaboration, Pfizer will initiate a Phase 1b/2 clinical trial to evaluate the anti-cancer activity of the combined agents, avelumab, talazoparib and bempegaldesleukin and separately avelumab, enzalutamide and bempegaldesleukin.
In September 2018, Nektar and Bristol-Myers Squibb initiated the Phase 3 study of bempegaldesleukin with nivolumab as compared to nivolumab monotherapy in participants with previously untreated unresectable or metastatic melanoma.
In July 2018, the U.S. Food and Drug Administration filed and accepted a New Drug Application (NDA) for NKTR-181, a first-in-class opioid analgesic, to treat chronic low back pain in adult patients new to opioid therapy. In February 2019, Nektar received notification from the FDA that the review period for NKTR-181 has been extended by three months. The new Prescription Drug User Fee Act (PDUFA) date is now August 29, 2019. The FDA extended the action date to allow time to review data from two additional preclinical studies that Nektar conducted which were requested by the FDA early on in our review process. The new preclinical data are supportive of the company's abuse liability package included in the NDA filing for NKTR-181.
In June 2018, Nektar presented data from the ongoing PIVOT study for bempegaldesleukin with nivolumab at the 2018 ASCO Meeting. Pre-specified efficacy criteria were achieved in three tumor types: first-line melanoma, first-line renal cell carcinoma and first-line urothelial cancer.
In May 2018, Nektar began dosing patients with systemic lupus erythematosus in a new Phase 1b multiple ascending dose study of NKTR-358, an IL-2 regulatory T cell stimulator, designed to correct the underlying immune system dysfunction found in patients with immune disorders.
In April 2018, Nektar announced a new clinical collaboration agreement with Takeda to evaluate bempegaldesleukin with TAK-659, a dual SYK and FLT-3 inhibitor in liquid and solid tumors. The first of these studies, a Phase 1b study in patients with Non-Hodgkin Lymphoma, was initiated in January of 2019.
In April 2018, Nektar presented preclinical data for its immuno-oncology pipeline at the 2018 AACR Annual Meeting. Preclinical data presented by Nektar researchers and collaborators demonstrated that bempegaldesleukin combines with multiple modalities including TLR agonism and adoptive cell therapy.
In April 2018, Nektar began dosing patients in the REVEAL Phase 1/2 study, which will evaluate NKTR-262, Nektar's wholly-owned novel toll-like receptor 7/8 agonist, in combination with bempegaldesleukin. The dose-escalation phase of the study is continuing.
In February 2018, Nektar and Bristol-Myers Squibb entered into a global development and commercialization agreement to evaluate the full potential of bempegaldesleukin with nivolumab in more than 20 indications in 9 tumor types.

 

 

The company also announced upcoming presentations and speaking engagements at the following scientific congresses during the first half of 2019:

ASCO-SITC Clinical Immuno-Oncology Symposium, San Francisco, CA

Oral presentation (Abstract #28): "Phase Ib: Preliminary clinical activity and immune activation for NKTR-262 (TLR 7/8 agonist) plus NKTR-214 (CD122-biased agonist) in patients (pts) with locally advanced or metastatic solid tumors (REVEAL Phase Ib/II Trial)"
oPresenter: Dr. Adi Diab, MD Anderson Cancer Center
oSession: Oral Abstract Session B
oSession Date & Time: March 1, 2019, 1:00 p.m.-2:15 p.m. Pacific Time

26th International Molecular Medicine Tri-Conference, San Francisco, CA

Presentation Title: "Advanced Cytokine Engineering for Immunotherapy"
oPresenter: Steven Doberstein, Ph.D., Nektar Therapeutics
oSession: Emerging Immuno-Oncology Targets Session
oSession Date & Time: March 12, 2019, at 11:25 a.m. Pacific Time

Keystone Symposia Cancer Immunotherapy: Mechanistic Insights to Improve Clinical Benefit, Whistler, BC, Canada

Presentation Title: "Intratumoral expansion of CD8+ T cells and depletion of Tregs after treatment with NKTR-214, a first-in-class, CD122-preferential IL-2 pathway agonist"
oPresenter: Willem Overwijk, Ph.D., Nektar Therapeutics
oSession: Immune Checkpoints: Basic Mechanisms and Novel Targets
oSession Date & Time: March 13, 2019, 8:00 a.m.-11:00 a.m. Pacific Time

CHI's Fourth Annual Immuno-Oncology Summit Europe, London, UK

Presentation Title: "Exploratory Studies up to IND with NKTR-255, a Memory T-Cell Stimulating Cytokine"
oPresenter: Saul Kivimae, Ph.D., Nektar Therapeutics
oSession: Importance of Cytokines/Innovative Approaches with Clinical Benefit
oSession Date and Time: March 19, 2019, at 16:45 Greenwich Mean Time

ICI-IO Combinations Summit, Boston, MA

Presentation Title: "Supercharging the Tumor Microenvironment: Lessons from NKTR-214 and OPDIVO"
oPresenter: Willem Overwijk, Ph.D., Nektar Therapeutics
oSession Date and Time: March 20, 2019, at 11:30 a.m. Eastern Time

American Association for Cancer Research (AACR) Annual Meeting 2019, Atlanta, GA

Abstract 2256/Poster Board 15: "Combination of neoantigen DNA plasmid vaccine VB10.NEO and NKTR-214, a CD122-biased immunostimulatory cytokine, induces strong neoantigen-specific T cell responses and sustained tumor regression in pre-clinical models," Granum, S., et al.
oSession: Clinical Research - Combination Immunotherapies 1
oSession Date and Time: April 1, 2019, 1:00 p.m.-5:00 p.m. Eastern Time
oLocation: Georgia World Congress Center, Exhibit Hall B, Poster Section 19

 

 

 

Abstract 3210/Poster Board 20: "A potential immunotherapeutic approach for the treatment of osteosarcoma," Wahba, A., et al.
oSession: Immunology – Combination Immunotherapies 2
oSession Date & Time: Tuesday, April 2, 2019, 8:00 a.m.-12:00 p.m. Eastern Time
oLocation: Georgia World Congress Center, Exhibit Hall B, Poster Section 2

 

Abstract 3265/Poster Board 15: "NKTR-255, a polymer-conjugated IL-15 enhances anti-tumor NK cell responses and synergizes with monoclonal antibodies to provide long-term survival in human lymphoma model," Miyazaki, T., et al.
oSession: Immunology - Novel Immunomodulatory Agents
oSession Date and Time: April 2, 2019, 8:00 a.m.-12:00 p.m. Eastern Time
oLocation: Georgia World Congress Center, Exhibit Hall B, Poster Section 25

15th Annual PEGS Boston Summit, Boston, MA

Keynote: "Harnessing Potent Cytokine Agonist Pathways by Polymer Engineering to Develop Novel Immune Therapeutic Agents"
oPresenter: Loui Madakamutil, Ph.D., Nektar Therapeutics
oSession: Latest Developments in Agonist Immunotherapy – Cytokines and OX40 Targets
oPresentation Date and Time: Thursday, April 11, 2019 1:50 p.m. Eastern Time

6th Immunotherapy of Cancer Conference (ITOC6), Vienna, Austria

Poster P2.12: "Mechanism of Action of NKTR-214, a first-in-class, CD122-preferential IL-2 pathway agonist"
oPresenter: Willem Overwijk, Ph.D., Nektar Therapeutics
oSession: Emerging Concepts/Novel Agents
oSession Dates and Times: April 11, 2019, at 18.20 Central European Time and April 12, 2019, from 14.00-14.30 Central European Time

 

Conference Call to Discuss Fourth Quarter and Year-End 2018 Financial Results
Nektar management will host a conference call to review the results beginning at 5:00 p.m. Eastern Time/2:00 p.m. Pacific Time today, Thursday, February 28, 2019.  This press release and a live audio-only webcast of the conference call can be accessed through a link that is posted on the home page and Investors section of the Nektar website: https://ir.nektar.com/events-and-presentations/events. The web broadcast of the conference call will be available for replay through Thursday, March 28, 2019.

To access the conference call, follow these instructions:

Dial: (877) 881-2183 (U.S.); (970) 315-0453 (international)
Passcode: 4988768 (Nektar Therapeutics is the host)

In the event that any non-GAAP financial measure is discussed on the conference call that is not described in the press release, or explained on the conference call, related information will be made available on the Investors page at the Nektar website as soon as practical after the conclusion of the conference call.

About Nektar

Nektar Therapeutics is a research-based, development stage biopharmaceutical company whose mission is to discover and develop innovative medicines to address the unmet medical needs of patients. Our R&D pipeline of new investigational medicines includes treatments for cancer, autoimmune disease and chronic pain. We leverage our proprietary and proven chemistry platform in the discovery and design of our new therapeutic candidates. Nektar is headquartered in San Francisco, California, with additional operations in Huntsville, Alabama and Hyderabad, India. Further information about Nektar and its drug development programs and capabilities may be found online at www.nektar.com.  

 

 

 

Cautionary Note Regarding Forward-Looking Statements

This press release contains uncertain or forward-looking statements which can be identified by words such as: "advance," "continue," "may," "will" and similar references to future periods. Examples of forward-looking statements include, among others, statements we make regarding the potential therapeutic benefits of and future development plans for our investigational products (including bempegaldesleukin, NKTR-181, NKTR-358, NKTR-262 and NKTR-255), the timing of receiving a response in connection with our pending new drug application, "NDA" for NKTR-181, and the results of clinical trials.  Forward-looking statements are neither historical facts nor assurances of future performance. Instead, they are based only on our current beliefs, expectations and assumptions and are subject to inherent uncertainties, risks and changes in circumstances that are difficult to predict and many of which are outside of our control. Our actual results may differ materially from those indicated in the forward-looking statements and you should not rely on such statements. Important factors that could cause our actual results to differ materially from those indicated in the forward-looking statements include: (i) the timing of the commencement or end of clinical studies and the availability of clinical data may be delayed or unsuccessful due to regulatory delays, slower than anticipated patient enrollment, manufacturing challenges, changing standards of care, evolving regulatory requirements, clinical trial design, clinical outcomes, and enrollment competition; (ii) the timing and probability of regulatory approval, if any, for NKTR-181 is uncertain and difficult to predict; (iii) scientific discovery of new medical breakthroughs is an inherently uncertain process and the future success of applying our technology platform to drug candidates (such as bempegaldesleukin, NKTR-262, NKTR-358, and NKTR-255) is therefore highly uncertain and unpredictable and one or more of these programs may fail; (iv) patents may not issue from our patent applications for our drug candidates, patents that have issued may not be enforceable, or additional intellectual property licenses from third parties may be required; and (v) certain other important risks and uncertainties set forth in Nektar's Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on November 8, 2018. Any forward-looking statement made by us in this press release is based only on information currently available to us and speaks only as of the date on which it is made. We undertake no obligation to update any forward-looking statement.

1. rINN (recommended International Nonproprietary Name)

Contact:

For Investors:
Jennifer Ruddock of Nektar Therapeutics
415-482-5585

Ashleigh Barreto of Nektar Therapeutics
628-895-0694

For Media:
Jodi Sievers of Nektar Therapeutics
415-482-5593

Dan Budwick of 1AB
973-271-6085
dan@1abmedia.com

 

 

 

NEKTAR THERAPEUTICS

CONDENSED CONSOLIDATED BALANCE SHEETS

(In thousands)
(Unaudited)

 

ASSETS  December 31, 2018   December 31, 2017 (1) 
Current assets:          
Cash and cash equivalents  $194,905   $4,762 
Short-term investments   1,140,445    291,370 
Accounts receivable   43,213    5,014 
Inventory   11,381    10,726 
Advance payments to contract manufacturers   26,450    7,155 
Other current assets   21,293    7,793 
Total current assets   1,437,687    326,820 
           
Long-term investments   582,889    57,088 
Property, plant and equipment, net   48,851    47,463 
Goodwill   76,501    76,501 
Other assets   4,244    994 
Total assets  $2,150,172   $508,866 
           
LIABILITIES AND STOCKHOLDERS’ EQUITY          
           
Current liabilities:          
Accounts payable  $5,854   $4,782 
Accrued compensation   9,937    8,263 
Accrued contract manufacturing expenses   23,841    3,845 
Accrued clinical trial expenses   14,700    9,461 
Other accrued expenses   9,087    6,219 
Interest payable   4,198    4,198 
Deferred revenue, current portion   13,892    18,949 
Other current liabilities   493    446 
Total current liabilities   82,002    56,163 
Senior secured notes, net   246,950    245,207 
Liability related to the sale of future royalties, net   82,911    94,655 
Deferred revenue, less current portion   10,744    19,021 
Other long-term liabilities   9,990    5,992 
Total liabilities   432,597    421,038 
           
Commitments and contingencies          
           
Stockholders’ equity:          
Preferred stock        
Common stock   17    15 
Capital in excess of par value   3,147,925    2,207,865 
Accumulated other comprehensive loss   (6,316)   (2,111)
Accumulated deficit   (1,424,051)   (2,117,941)
Total stockholders’ equity   1,717,575    87,828 
Total liabilities and stockholders’ equity  $2,150,172   $508,866 

 

(1) The consolidated balance sheet at December 31, 2017 has been derived from the audited financial statements at that date but does not include all of the information and notes required by generally accepted accounting principles in the United States for complete financial statements

 

 

 

 

NEKTAR THERAPEUTICS

CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS

(In thousands, except per share information)
(Unaudited)

 

   Three Months Ended December 31,   Year Ended December 31, 
   2018   2017   2018   2017 
                 
Revenue:                    
Product sales  $4,360   $7,791   $20,774   $32,688 
Royalty revenue   12,078    9,574    41,976    33,527 
Non-cash royalty revenue related to sale of future royalties   8,971    9,164    33,308    30,531 
License, collaboration and other revenue   14,417    68,937    1,097,265    210,965 
Total revenue   39,826    95,466    1,193,323    307,711 
                     
Operating costs and expenses:                    
Cost of goods sold   7,461    9,753    24,412    30,547 
Research and development   108,883    81,429    399,536    268,461 
General and administrative   23,777    12,337    81,443    52,364 
Impairment of equipment and other costs for terminated program       15,981        15,981 
Total operating costs and expenses   140,121    119,500    505,391    367,353 
                     
Income (loss) from operations   (100,295)   (24,034)   687,932    (59,642)
                     
Non-operating income (expense):                    
Interest expense   (5,415)   (5,633)   (21,582)   (22,085)
Non-cash interest expense on liability related to sale of future royalties   (6,388)   (5,334)   (21,196)   (18,869)
Interest income and other income (expense), net   12,048    1,357    37,571    4,520 
Total non-operating income (expense), net   245    (9,610)   (5,207)   (36,434)
                     
Income (loss) before provision for income taxes   (100,050)   (33,644)   682,725    (96,076)
                     
Provision (benefit) for income taxes   (1,838)   182    1,412    616 
Net income (loss)  $(98,212)  $(33,826)  $681,313   $(96,692)
                     
Net income (loss) per share:                    
Basic  $(0.57)  $(0.21)  $4.02   $(0.62)
Diluted  $(0.57)  $(0.21)  $3.78   $(0.62)
                     
Weighted average shares outstanding used in computing net income (loss) per share:                    
Basic   173,271    158,324    169,600    155,953 
Diluted   173,271    158,324    180,119    155,953 

 

 

 

 

NEKTAR THERAPEUTICS

CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS

(In thousands)

(Unaudited)

 

   Year Ended December 31, 
   2018   2017 
Cash flows from operating activities:          
Net income (loss)  $681,313   $(96,692)
Adjustments to reconcile net income (loss) to net cash provided by (used in) operating activities:          
Non-cash royalty revenue related to sale of future royalties   (33,308)   (30,531)
Non-cash interest expense on liability related to sale of future royalties   21,196    18,869 
Stock-based compensation   88,101    36,615 
Depreciation and amortization   10,870    14,741 
Impairment of equipment from terminated program       15,081 
Accretion of discounts, net and other non-cash transactions   (10,952)   (881)
Changes in operating assets and liabilities:          
Accounts receivable   (25,505)   10,664 
Inventory   (655)   383 
Other assets   (31,652)   (4,800)
Accounts payable   971    2,074 
Accrued compensation   1,674    (10,017)
Other accrued expenses   27,947    7,277 
Deferred revenue   (15,331)   (28,269)
Other liabilities   3,545    (14,928)
Net cash provided by (used in) operating activities   718,214    (80,414)
           
Cash flows from investing activities:          
Purchases of investments   (2,271,250)   (404,425)
Maturities of investments   890,957    347,743 
Sales of investments   11,963    37,549 
Purchases of property, plant and equipment   (14,239)   (9,676)
Sales of property and plant   2,633     
Net cash used in investing activities   (1,379,936)   (28,809)
           
Cash flows from financing activities:          
Payment of capital lease obligations       (5,131)
Issuance of common stock   790,231     
Proceeds from shares issued under equity compensation plans   61,735    59,522 
Net cash provided by financing activities   851,966    54,391 
           
Effect of exchange rates on cash and cash equivalents   (101)   (46)
Net increase (decrease) in cash and cash equivalents   190,143    (54,878)
Cash and cash equivalents at beginning of year   4,762    59,640 
Cash and cash equivalents at end of year  $194,905   $4,762 
           
Supplemental disclosure of cash flow information:          
Cash paid for interest  $19,471   $20,116 
Cash paid for income taxes  $618   $556