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Disclosure - Organization and Summary of Significant Accounting Policies link:presentationLink link:calculationLink link:definitionLink 0000011 - Disclosure - Cash and Investments in Marketable Securities link:presentationLink link:calculationLink link:definitionLink 0000012 - Disclosure - Inventory link:presentationLink link:calculationLink link:definitionLink 0000013 - Disclosure - Property, Plant and Equipment link:presentationLink link:calculationLink link:definitionLink 0000014 - Disclosure - Operating Leases link:presentationLink link:calculationLink link:definitionLink 0000015 - Disclosure - Co-Development Agreement with SFJ Pharmaceuticals and Development Derivative Liability link:presentationLink link:calculationLink link:definitionLink 0000016 - Disclosure - Liabilities Related to the Sales of Future Royalties link:presentationLink link:calculationLink link:definitionLink 0000017 - Disclosure - Commitments and Contingencies link:presentationLink link:calculationLink link:definitionLink 0000018 - Disclosure - Stockholders' Equity link:presentationLink link:calculationLink link:definitionLink 0000019 - Disclosure - License and Collaboration Agreements link:presentationLink link:calculationLink link:definitionLink 0000020 - Disclosure - Restructuring, Impairment and Other Costs of Terminated Program link:presentationLink link:calculationLink link:definitionLink 0000021 - Disclosure - Stock-Based Compensation link:presentationLink link:calculationLink link:definitionLink 0000022 - Disclosure - Income Taxes link:presentationLink link:calculationLink link:definitionLink 0000023 - Disclosure - Segment Reporting link:presentationLink link:calculationLink link:definitionLink 0000024 - Disclosure - Organization and Summary of Significant Accounting Policies (Policies) link:presentationLink link:calculationLink link:definitionLink 0000025 - Disclosure - Cash and Investments in Marketable Securities (Tables) link:presentationLink link:calculationLink link:definitionLink 0000026 - Disclosure - Inventory (Tables) link:presentationLink link:calculationLink link:definitionLink 0000027 - Disclosure - Property, Plant and Equipment (Tables) link:presentationLink link:calculationLink link:definitionLink 0000028 - Disclosure - Operating Leases (Tables) link:presentationLink link:calculationLink link:definitionLink 0000029 - Disclosure - Co-Development Agreement with SFJ Pharmaceuticals and Development Derivative Liability (Tables) link:presentationLink link:calculationLink link:definitionLink 0000030 - Disclosure - Liabilities Related to the Sales of Future Royalties (Tables) link:presentationLink link:calculationLink link:definitionLink 0000031 - Disclosure - Stockholders' Equity (Tables) link:presentationLink link:calculationLink link:definitionLink 0000032 - Disclosure - License and Collaboration Agreements (Tables) link:presentationLink link:calculationLink link:definitionLink 0000033 - Disclosure - Restructuring, Impairment and Other Costs of Terminated Program (Tables) link:presentationLink link:calculationLink link:definitionLink 0000034 - 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Disclosure - Operating Leases - Schedule of Future Minimum Lease Payments for Operating Leases (Details) link:presentationLink link:calculationLink link:definitionLink 0000048 - Disclosure - Co-Development Agreement with SFJ Pharmaceuticals and Development Derivative Liability - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 0000049 - Disclosure - Co-Development Agreement with SFJ Pharmaceuticals and Development Derivative Liability - Schedule of Fair Value of Derivative Liability (Details) link:presentationLink link:calculationLink link:definitionLink 0000050 - Disclosure - Liabilities Related to the Sales of Future Royalties - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 0000051 - Disclosure - Liabilities Related to the Sales of Future Royalties - Schedule of Liability Related to Potential Future Royalties (Detail) link:presentationLink link:calculationLink link:definitionLink 0000052 - 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Summary of Restructuring Costs (Details) link:presentationLink link:calculationLink link:definitionLink 0000059 - Disclosure - Restructuring, Impairment and Other Costs of Terminated Program - Restructuring Reserve Rollforward (Details) link:presentationLink link:calculationLink link:definitionLink 0000060 - Disclosure - Restructuring, Impairment and Other Costs of Terminated Program - Sublease Information (Details) link:presentationLink link:calculationLink link:definitionLink 0000061 - Disclosure - Restructuring, Impairment and Other Costs of Terminated Program - Schedule of Property, Plant and Equipment (Details) link:presentationLink link:calculationLink link:definitionLink 0000062 - Disclosure - Stock-Based Compensation - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 0000063 - Disclosure - Stock-Based Compensation - Schedule of Stock-Based Compensation Expense (Details) link:presentationLink link:calculationLink link:definitionLink 0000064 - 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