0001001 - Document - Cover Page link:presentationLink link:calculationLink link:definitionLink 1001002 - Statement - CONDENSED CONSOLIDATED BALANCE SHEETS link:presentationLink link:calculationLink link:definitionLink 1002003 - Statement - CONDENSED CONSOLIDATED BALANCE SHEETS (Unaudited) (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 1003004 - Statement - CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS link:presentationLink link:calculationLink link:definitionLink 1004005 - Statement - CONDENSED CONSOLIDATED STATEMENTS OF COMPREHENSIVE LOSS link:presentationLink link:calculationLink link:definitionLink 1005006 - Statement - CONDENSED CONSOLIDATED STATEMENTS OF STOCKHOLDERS’ EQUITY link:presentationLink link:calculationLink link:definitionLink 1006007 - Statement - CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS link:presentationLink link:calculationLink link:definitionLink 2101101 - Disclosure - Organization and Summary of Significant Accounting Policies link:presentationLink link:calculationLink link:definitionLink 2202201 - Disclosure - Organization and Summary of Significant Accounting Policies (Policies) link:presentationLink link:calculationLink link:definitionLink 2403401 - Disclosure - Organization and Summary of Significant Accounting Policies - Additional Information (Detail) link:presentationLink link:calculationLink link:definitionLink 2104102 - Disclosure - Cash and Investments in Marketable Securities link:presentationLink link:calculationLink link:definitionLink 2305301 - Disclosure - Cash and Investments in Marketable Securities (Tables) link:presentationLink link:calculationLink link:definitionLink 2406402 - Disclosure - Cash and Investments in Marketable Securities - Cash and Investments in Marketable Securities, Including Cash Equivalents (Detail) link:presentationLink link:calculationLink link:definitionLink 2407403 - Disclosure - Cash and Investments in Marketable Securities - Additional Information (Detail) link:presentationLink link:calculationLink link:definitionLink 2408404 - Disclosure - Cash and Investments in Marketable Securities - Portfolio of Cash and Investments in Marketable Securities (Detail) link:presentationLink link:calculationLink link:definitionLink 2109103 - Disclosure - Inventory link:presentationLink link:calculationLink link:definitionLink 2310302 - Disclosure - Inventory (Tables) link:presentationLink link:calculationLink link:definitionLink 2411405 - Disclosure - Inventory (Details) link:presentationLink link:calculationLink link:definitionLink 2112104 - Disclosure - Co-Development Agreement with SFJ Pharmaceuticals and Development Derivative Liability link:presentationLink link:calculationLink link:definitionLink 2313303 - Disclosure - Co-Development Agreement with SFJ Pharmaceuticals and Development Derivative Liability (Tables) link:presentationLink link:calculationLink link:definitionLink 2414406 - Disclosure - Co-Development Agreement with SFJ Pharmaceuticals and Development Derivative Liability - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 2415407 - Disclosure - Co-Development Agreement with SFJ Pharmaceuticals and Development Derivative Liability - Fair Value of Derivative Liability (Details) link:presentationLink link:calculationLink link:definitionLink 2116105 - Disclosure - Liabilities Related to Sales of Future Royalties link:presentationLink link:calculationLink link:definitionLink 2317304 - Disclosure - Liabilities Related to Sales of Future Royalties (Tables) link:presentationLink link:calculationLink link:definitionLink 2418408 - Disclosure - Liabilities Related to Sales of Future Royalties - Activity Within the Liability Account (Details) link:presentationLink link:calculationLink link:definitionLink 2419409 - Disclosure - Liabilities Related to Sales of Future Royalties - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 2120106 - Disclosure - Commitments and Contingencies link:presentationLink link:calculationLink link:definitionLink 2421410 - Disclosure - Commitments and Contingencies - Additional Information (Detail) link:presentationLink link:calculationLink link:definitionLink 2122107 - Disclosure - License and Collaboration Agreements link:presentationLink link:calculationLink link:definitionLink 2423411 - Disclosure - License and Collaboration Agreements - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 2124108 - Disclosure - Restructuring, Impairment and Other Costs of Terminated Program link:presentationLink link:calculationLink link:definitionLink 2325305 - Disclosure - Restructuring, Impairment and Other Costs of Terminated Program (Tables) link:presentationLink link:calculationLink link:definitionLink 2426412 - Disclosure - Restructuring, Impairment and Other Costs of Terminated Program - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 2427413 - Disclosure - Restructuring, Impairment and Other Costs of Terminated Program - Summary of Restructuring Costs (Details) link:presentationLink link:calculationLink link:definitionLink 2428414 - Disclosure - Restructuring, Impairment and Other Costs of Terminated Program - Restructuring Reserve Rollforward (Details) link:presentationLink link:calculationLink link:definitionLink 2429415 - Disclosure - Restructuring, Impairment and Other Costs of Terminated Program - Sublease Information (Details) link:presentationLink link:calculationLink link:definitionLink 2430416 - Disclosure - Restructuring, Impairment and Other Costs of Terminated Program - Schedule of Property, Plant and Equipment (Details) link:presentationLink link:calculationLink link:definitionLink 2131109 - Disclosure - Stock-Based Compensation link:presentationLink link:calculationLink link:definitionLink 2332306 - Disclosure - Stock-Based Compensation (Tables) link:presentationLink link:calculationLink link:definitionLink 2433417 - Disclosure - Stock-Based Compensation - Additional Information (Detail) link:presentationLink link:calculationLink link:definitionLink 2434418 - Disclosure - Stock-Based Compensation - Stock-Based Compensation Expense (Detail) link:presentationLink link:calculationLink link:definitionLink 2435419 - Disclosure - Stock-Based Compensation - Activity (Detail) link:presentationLink link:calculationLink link:definitionLink 2136110 - Disclosure - Net Loss Per Share link:presentationLink link:calculationLink link:definitionLink 2337307 - Disclosure - Net Loss Per Share (Tables) link:presentationLink link:calculationLink link:definitionLink 2438420 - Disclosure - Net Loss Per Share (Detail) link:presentationLink link:calculationLink link:definitionLink