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Feb 28, 2023
Nektar Therapeutics Reports Fourth Quarter and Year-End 2022 Financial Results

SAN FRANCISCO, Feb. 28, 2023 /PRNewswire/ -- Nektar Therapeutics (Nasdaq: NKTR) today reported financial results for the fourth quarter and full year ended December 31, 2022.

Cash and investments in marketable securities at December 31, 2022, were approximately $505.0 million as compared to $798.8 million at December 31, 2021.

"We are committed to ensuring that our existing cash can support a runway through at least the middle of 2025," said Howard W. Robin, President and CEO of Nektar. "This will enable us to advance our current pipeline to reach value-enhancing milestones. As a result, and as we stated on our analyst call last week, we will be making additional changes at Nektar to significantly reduce operating costs to meet that commitment."

Summary of Financial Results

Revenue in the fourth quarter of 2022 was $22.0 million as compared to $25.0 million in the fourth quarter of 2021. Revenue for the year ended December 31, 2022 was $92.1 million as compared to $101.9 million in 2021. Revenue for 2022 was lower compared to 2021, driven by a decrease in non-cash royalty revenue.

Total operating costs and expenses in the fourth quarter of 2022 were $74.5 million as compared to $137.9 million in the fourth quarter of 2021. Total operating costs and expenses for the full year 2022 were $468.2 million as compared to $548.0 million in 2021. Operating costs and expenses for both the fourth quarter and the full year 2022 decreased as compared to 2021 primarily due to the wind down of the bempegaldesleukin program, partially offset by severance expense and non-cash lease and equipment impairment charges.

R&D expense in the fourth quarter of 2022 was $34.7 million as compared to $99.6 million for the fourth quarter of 2021. R&D expense for the year ended December 31, 2022 was $218.3 million as compared to $400.3 million in 2021. R&D expense decreased for both the fourth quarter and full year 2022 primarily due to the wind down of the bempegaldesleukin program. The clinical trial and related employee compensation costs for the wind down of the bempegaldesleukin program are reported in restructuring, impairment and other costs of terminated program, discussed below.

G&A expense was $21.9 million in the fourth quarter of 2022 and $32.1 million in the fourth quarter of 2021. G&A expense for the full year 2022 was $92.3 million as compared to $122.8 million in 2021. G&A expense decreased for both the fourth quarter and full year 2022 primarily due to the wind down of the bempegaldesleukin program.

Restructuring, impairment and other costs of the terminated program were $11.6 million in the fourth quarter of 2022 and $135.9 million in the full year 2022. The full year 2022 amount includes $65.8 million in non-cash lease and equipment impairment charges, $30.9 million in employee severance expense and $31.7 million for clinical trial and related employee compensation costs for the wind down of the bempegaldesleukin program, as well as $7.5 million in other restructuring costs.

Net loss for the fourth quarter of 2022 was $59.7 million or $0.32 basic and diluted loss per share as compared to a net loss of $145.6 million or $0.79 basic and diluted loss per share in the fourth quarter of 2021. Net loss for the year ended December 31, 2022 was $368.2 million or $1.97 basic and diluted loss per share as compared to a net loss of $523.8 million or $2.86 basic and diluted loss per share in 2021.

On February 23, 2023, Nektar announced topline data from a Phase 2 study of rezpegaldesleukin in adults with moderately-to-severely active systemic lupus erythematosus (SLE) (https://ir.nektar.com/news-releases/news-release-details/nektar-therapeutics-announces-phase-2-topline-data) and conducted a call with analysts and investors.

As a result of this call, Nektar will not host its regular quarterly financial results conference call for the fourth quarter and year-end 2022.  Nektar's Form 10-K for the year ended December 31, 2022 was filed on February 28, 2023.

About Nektar Therapeutics

Nektar Therapeutics is a biopharmaceutical company with a robust, wholly owned R&D pipeline of investigational medicines in oncology and immunology as well as a portfolio of approved partnered medicines. Nektar is headquartered in San Francisco, California, with additional operations in Huntsville, Alabama. Further information about the company and its drug development programs and capabilities may be found online at http://www.nektar.com.

Cautionary Note Regarding Forward-Looking Statements

This press release contains forward-looking statements which can be identified by words such as: "will," "may," "advance," "support," "develop," "provide" and similar references to future periods. Examples of forward-looking statements include, among others, statements we make regarding the therapeutic potential of, and future development plans for rezpegaldesleukin (formerly NKTR-358), NKTR-255 and our other drug candidates in research programs, the prospects and plans for our collaborations with other companies, the timing of the initiation of clinical studies and the data readouts for our drug candidates, our expectations (including our expected charges and cost savings) following our 2022 corporate restructuring and  reorganization plan and workforce reduction, and our expected working capital and cash runway. Forward-looking statements are neither historical facts nor assurances of future performance. Instead, they are based only on our current beliefs, expectations and assumptions regarding the future of our business, future plans and strategies, anticipated events and trends, the economy and other future conditions. Because forward-looking statements relate to the future, they are subject to inherent uncertainties, risks and changes in circumstances that are difficult to predict and many of which are outside of our control. Our actual results may differ materially from those indicated in the forward-looking statements. Therefore, you should not rely on any of these forward-looking statements. Important factors that could cause our actual results to differ materially from those indicated in the forward-looking statements include, among others: (i) our statements regarding the therapeutic potential of rezpegaldesleukin, NKTR-255 and our other drug candidates are based on preclinical and clinical findings and observations and are subject to change as research and development continue; (ii) rezpegaldesleukin, NKTR-255 and our other drug candidates are investigational agents and continued research and development for these drug candidates is subject to substantial risks, including negative safety and efficacy findings in ongoing clinical studies (notwithstanding positive findings in earlier preclinical and clinical studies); (iii) rezpegaldesleukin, NKTR-255 and our other drug candidates are in various stages of clinical development and the risk of failure is high and can unexpectedly occur at any stage prior to regulatory approval; (iv) the timing of the commencement or end of clinical trials and the availability of clinical data may be delayed or unsuccessful due to challenges caused by the COVID-19 pandemic, regulatory delays, slower than anticipated patient enrollment, manufacturing challenges, changing standards of care, evolving regulatory requirements, clinical trial design, clinical outcomes, competitive factors, or delay or failure in ultimately obtaining regulatory approval in one or more important markets; (v) we may not achieve the expected cost savings we expect from our 2022 corporate restructuring and reorganization plan and we may undertake additional restructuring and cost-saving activities in the future, (vi) patents may not issue from our patent applications for our drug candidates, patents that have issued may not be enforceable, or additional intellectual property licenses from third parties may be required; and (vii) certain other important risks and uncertainties set forth in our Annual Report on Form 10-K filed with the Securities and Exchange Commission on February 28, 2023. Any forward-looking statement made by us in this press release is based only on information currently available to us and speaks only as of the date on which it is made. We undertake no obligation to update any forward-looking statement, whether written or oral, that may be made from time to time, whether as a result of new information, future developments or otherwise.

Contact:

For Investors:
Vivian Wu of Nektar Therapeutics
628-895-0661

For Media:
David Rosen of Argot Partners
(212) 600-1902
david.rosen@argotpartners.com

 

NEKTAR THERAPEUTICS


CONDENSED CONSOLIDATED BALANCE SHEETS


(In thousands)


(Unaudited)


















                                        ASSETS






December 31, 2022


December 31, 2021(1)


Current assets:















Cash and cash equivalents










$                      88,227


$                        25,218



Short-term investments










416,750


708,737



Accounts receivable










5,981


22,492



Inventory










19,202


15,801



Other current assets










15,808


23,333




Total current assets










545,968


795,581


















Long-term investments










-


64,828


Property, plant and equipment, net










32,451


60,510


Operating lease right-of-use assets









53,435


117,025


Goodwill










76,501


76,501


Other assets










2,245


2,744




Total assets










$                    710,600


$                   1,117,189


















                        LIABILITIES AND STOCKHOLDERS' EQUITY





















Current liabilities:















Accounts payable










$                      12,980


$                          9,747



Accrued compensation










9,582


15,735



Accrued clinical trial expenses










12,262


26,809



Other accrued expenses










14,713


15,468



Operating lease liabilities, current portion









18,667


17,441




Total current liabilities










68,204


85,200


















Operating lease liabilities, less current portion








112,829


125,736


Development derivative liability










-


27,726


Liabilities related to the sales of future royalties, net








155,378


195,427


Other long-term liabilities










7,551


3,592




Total liabilities










343,962


437,681


















Commitments and contingencies






























Stockholders' equity:















Common stock










19


19



Capital in excess of par value










3,574,719


3,516,641



Accumulated other comprehensive loss









(6,907)


(4,157)



Accumulated deficit










(3,201,193)


(2,832,995)




Total stockholders' equity










366,638


679,508



Total liabilities and stockholders' equity









$                    710,600


$                  1,117,189


















(1) The consolidated balance sheet at December 31, 2022 has been derived from the audited financial statements at that date but does not include all of the
information and notes required by generally accepted accounting principles in the United States for complete financial statements.

 

NEKTAR THERAPEUTICS

CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS

(In thousands, except per share information)

(Unaudited)     
























Three months ended December 31,


Year ended December 31,









2022


2021


2022


2021
















Revenue:














Product sales






$                        4,379


$                        5,890


$              20,348


$                      23,725


Non-cash royalty revenue related to the
sales of future royalties



17,627


19,079


69,794


77,746


License, collaboration and other revenue





17


40


1,913


436

Total revenue






22,023


25,009


92,055


101,907
















Operating costs and expenses:














Cost of goods sold






6,233


6,163


21,635


24,897


Research and development






34,740


99,614


218,323


400,269


General and administrative






21,939


32,142


92,333


122,844


Restructuring, impairment and other costs
of terminated program



11,580


-


135,930


-

Total operating costs and expenses





74,492


137,919


468,221


548,010




Loss from operations






(52,469)


(112,910)


(376,166)


(446,103)
















Non-operating income (expense):














Change in fair value of development
derivative liability




-


(383)


33,427


(8,023)


Non-cash interest expense on liabilities
related to the sales of future royalties


(7,201)


(8,127)


(28,911)


(47,313)


Loss on revaluation of liability related to
the sale of future royalties



-


(24,410)


-


(24,410)


Interest income and other income (expense), net




3,126


181


6,667


2,569

Total non-operating income (expense), net






(4,075)


(32,739)


11,183


(77,177)
















Loss before provision for income taxes





(56,544)


(145,649)


(364,983)


(523,280)
















Provision for income taxes






3,144


(4)


3,215


557

Net loss






$                    (59,688)


$                   (145,645)


$           (368,198)


$                   (523,837)































Basic and diluted net loss per share





$                        (0.32)


$                         (0.79)


$                 (1.97)


$                         (2.86)
















Weighted average shares outstanding used in
computing basic and diluted net loss per share


188,237


184,964


187,138


183,298

 

NEKTAR THERAPEUTICS

CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS

(In thousands)

(Unaudited)









Year ended December 31,









2022


2021

Cash flows from operating activities:








Net loss






$                  (368,198)


$                  (523,837)

Adjustments to reconcile net loss to net cash used in operating activities:






Non-cash royalty revenue related to the sales of future royalties



(69,794)


(77,746)


Non-cash interest expense on liabilities related to the sales of future royalties 


28,911


47,313


Loss on revaluation of liability related to the sale of future royalties



-


24,410


Change in fair value of development derivative liability




(33,427)


8,023


Non-cash research and development expense




4,951


16,703


Stock-based compensation 






57,320


94,674


Depreciation and amortization 






13,030


14,146


Deferred income tax expense






2,708


(102)


Impairment of right-of-use asset and property, plant and equipment



65,761


-


(Gain) loss on sale or disposal of property, plant and equipment, net



(3,326)


-


Amortization of premiums (discounts), net and other non-cash transactions


(2,435)


6,730

Changes in operating assets and liabilities:









Accounts receivable






16,511


12,397


Inventory






(3,401)


(509)


Operating leases, net






(2,680)


2,340


Other assets 






6,906


(2,586)


Accounts payable 






3,103


(11,690)


Accrued compensation 






(6,153)


1,203


Other accrued expenses 






(12,734)


(23,524)


Deferred revenue 






(1,060)


(605)

Net cash used in operating activities 





(304,007)


(412,660)












Cash flows from investing activities:









Purchases of investments 






(467,914)


(960,689)


Maturities of investments 






826,229


1,166,951


Sales of investments






-


11,504


Purchases of property, plant and equipment 




(5,676)


(14,989)


Sales of property, plant and equipment 





13,196


-

Net cash provided by investing activities 





365,835


202,777












Cash flows from financing activities:









Cash receipts from development derivative liability




750


3,000


Proceeds from shares issued under equity compensation plans



758


33,238

Net cash provided by financing activities 




1,508


36,238












Effect of foreign exchange rates on cash and cash equivalents 



(327)


(92)

Net increase (decrease) in cash and cash equivalents 




63,009


(173,737)

Cash and cash equivalents at beginning of year




25,218


198,955

Cash and cash equivalents at end of year





$                      88,227


$                       25,218












Supplemental disclosure of cash flow information:







Cash paid for income taxes






$                           272


$                            325

Operating lease right-of-use assets recognized in exchange for lease liabilities


$                                -


$                         1,057

 

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SOURCE Nektar Therapeutics